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Effect of single gallium arsenide exposure on some biochemical variables in porphyrin metabolism in rats
Author(s) -
Flora S. J. S.,
Gupta S. Das
Publication year - 1992
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550120508
Subject(s) - dehydratase , porphobilinogen , zinc protoporphyrin , metabolism , chemistry , protoporphyrin , porphobilinogen synthase , excretion , gallium arsenide , urinary system , porphyrin , medicine , zinc , endocrinology , biochemistry , heme , enzyme , materials science , optoelectronics , organic chemistry
Gallium arsenide (GaAs) inhibited, dose dependently, δ‐aminolevulinic acid dehydratase (ALAD) activity in blood (as observed on days 1, 7 and 15), liver and brain (on day 15) after a single oral treatment. Levels of blood zinc protoporphyrin (ZPP) and urinary Δ‐aminolevulinic acid (ALA) excretion were elevated on day 7 and day 15 following exposure to 2000 mg kg −1 GaAs. A dose‐dependent increase in blood As contents was observed while blood Ga was detectable only at higher doses.