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The influence of fenarimol on dna synthesis and mitotic activity in rat liver
Author(s) -
Palut Danuta,
Ludwicki Jan,
SzlȩLzakKopeć Joanna
Publication year - 1992
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550120411
Subject(s) - dna synthesis , hyperplasia , mitosis , necrosis , body weight , medicine , endocrinology , toxicity , chemistry , mitotic index , pharmacology , biology , dna , biochemistry , microbiology and biotechnology
Fenarimol administered in one single oral dose of 125 or 62.5 mg kg −1 body wt. day −1 , respectively, stimulated rat liver enlargement at a dose‐independent rate. Three single doses of fenarimol produced dose‐dependent liver growth, whereas five single doses caused no further increase in liver weight. This increase was accompanied by an increase in hepatic DNA synthesis and mitotic activity, with a peak on the first day after the beginning of the experiments. The increase in binuclear hepatocytes and signs of necrosis suggested that the hepatomitogenic effect reflected a compensatory hyperplasia. After both three and five single doses the hepatomitogenic effect was supressed, as a result of tolerance development.