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Inhalation exposure of rats to metal aerosol. I. Effects on pulmonary surfactant and ascorbic acid
Author(s) -
Kováčiková Zuzana,
Chorvatovičová Darina
Publication year - 1992
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550120113
Subject(s) - ascorbic acid , pulmonary surfactant , inhalation , inhalation exposure , aerosol , chemistry , medicine , environmental chemistry , pharmacology , anesthesia , organic chemistry , biochemistry , food science
Female albino Wistar rats were exposed to <5 μm particles separated from nickel refinery waste. The generated aerosol of 50 mg m −3 mainly consisted of metal oxides, the most toxic being NiO and Cr 2 O 3 . The exposure of 5 h per day, 5 days per week, lasted for 4 weeks or 4 months. At the end of the exposure period the amounts of pulmonary surfactant and ascorbic acid were estimated in both exposed and control rats. The amount of pulmonary surfactant was elevated after both exposure times, while ascorbic acid increased significantly ( P < 0.02) only after 4 weeks of exposure.