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Carcinogenic effects of Bis(2,3‐dibromopropyl)‐phosphate in wistar rats
Author(s) -
Takada Koichi,
Naito Katsushi,
Kobayashi Kazuo,
Tobe Masuo,
Kurokawa Yuji,
Fukuoka Masamichi
Publication year - 1991
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550110505
Subject(s) - carcinogen , incidence (geometry) , small intestine , phosphate , medicine , hepatocellular carcinoma , biology , endocrinology , pathology , physiology , biochemistry , physics , optics
Abstract Four groups of 40 Wistar rats of each sex per dose level were fed diets containing 0, 80, 400 or 2000 ppm of the magnesium salt of bis(2,3‐dibromopropyl)phosphate (Bis‐BP) for 24 months. A high incidence of tumours was induced, in both sexes, in the digestive system. Tumours included papillomas and adenocarcinomas of the tongue, oesophagus and forestomach, adenocarcinomas of the intestine and hepatocellular adenomas (neoplastic nodules) and carcinomas. Pre‐terminal mortalities were associated with an increased incidence of forestomach papillomas in both sexes, adenocarcinomas of the small intestine in male rats and increased incidence of hepatocellular carcinomas in females. The data suggest that Bis‐BP is a more potent proximate carcinogen than tris‐(2,3‐dibromopropyl)phosphate (Tris‐BP).