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Dithiocarbamate analog N ‐(4‐methoxybenzyl)‐ N ‐dithiocarboxy‐D‐glucamine reduces the retention of ingested cadmium in rats
Author(s) -
Kargačin B.,
Kostial K.,
Arežina R.,
Singh P. K.,
Jones M. M.,
Cikrt M.
Publication year - 1991
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550110503
Subject(s) - dithiocarbamate , chemistry , cadmium , oral administration , pharmacology , antidote , toxicity , intraperitoneal injection , retention time , chromatography , medicine , organic chemistry
This study was performed to evaluate the effect of oral and intraperitoneal treatment with N ‐(4‐methoxybenzyl) D‐glucamine dithiocarbamate monohydrate (MeOBDCG) after a single oral administration of 115m Cd to 6‐week‐old rats. Oral treatment reduced the retention of 115m Cd in the whole body, gut, liver and kidney by 5, 3, 4 and 3 times respectively, and intraperitoneal treatment reduced the retention by 7,2.5, 16 and 4.5 times, respectively. This finding is new, since it was believed that oral dithiocarbamate treatment would increase the toxicity and absorption of ingested cadmium.