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Effects of soman on calcium uptake in microsomes and mitochondria from rabbit aorta
Author(s) -
Hu ChaoYu,
Hsu ChiaHsuh,
Robinson Casey P.
Publication year - 1991
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550110411
Subject(s) - soman , calcium , microsome , chemistry , pharmacology , calcium in biology , mitochondrion , intracellular , medicine , endocrinology , biochemistry , biology , in vitro , acetylcholinesterase , enzyme
Daily administration of soman for several days results in several alterations in the vascular neuroeffector system. To determine whether or not soman alters intracellular Ca 2+ uptake, the effects of acute exposure to soman or 7‐day administration of 5μg kg −1 of soman on the capacity of microsomes and mitochondria from rabbit aortic vascular smooth muscle to take up 45 Ca 2+ were determined. Acute exposure to soman concentrations of 1–100 μM did not alter significantly ( P >0.05) 45 Ca 2+ uptake by either microsomes or mitochondria. On the other hand, 7‐day soman administration markedly reduced ( P <0.05) 45 Ca 2+ uptake by both microsomes and mitochondria. Thus, calcium uptake and intracellular calcium uptake‐dependent responses will be affected by repeated soman administration.