Premium
Interaction of ethanol and xylene in their effects on erythrocytes and other haematological parameters in the rat
Author(s) -
WrońskaNoferδ Teresa,
Rosin Janusz,
Bartosz Grzegorz
Publication year - 1991
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550110410
Subject(s) - ethanol , chemistry , macrocytosis , xylene , inhalation , toluene , erythrocyte membrane , toxicity , membrane , biochemistry , chromatography , organic chemistry , anesthesia , medicine , vitamin b12
Abstract Rats were given ethanol in drinking water for 8 months, followed by inhalation exposure (5 h daily) to 12.000 mg m −3 xylene for 9 days. Combined exposure to xylene and ethanol induced the same changes in the haematological, biochemical and biophysical parameters of the erythrocyte membrane as those found previously in our experiment with toluene–ethanol. Macrocytosis, a decrease in sedimentation rate and erthrocyte packing difference, as well as decreased fluidity of the erythrocytes membrane in the middle zone of the lipid bilayer, were the most significant changes of exposure to ethanol and xylene.