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Possible involvement of 1,2‐diacetylbenzene in diethylbenzene‐induced neuropathy in rats
Author(s) -
Gagnaire F.,
Ensminger A.,
Marignac B.,
de Ceaurriz J.
Publication year - 1991
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550110406
Subject(s) - neurotoxicity , urine , intraperitoneal injection , toxicity , chemistry , medicine , endocrinology , peripheral neuropathy , nerve conduction , diabetes mellitus
The role of 1,2‐diacetylbenzene (1,2‐DAB) in the peripheral nerve toxicity of 1,2‐diethylbenzene (1,2‐DEB) was investigated in rats. Gas chromatography‐mass spectrometry identified 1,2‐DAB in the urine samples of rats given 165 mg kg −1 1,2‐DEB orally on four consecutive days. 1,2‐DAB shared not only the ability of 1,2‐DEB to cause bluish discoloration of skin, internal organs and urine, but unlike 1,2‐DEB it turned hair blue at the site of intraperitoneal injection. Intraperitoneal administration of 10 mg kg −1 and 20 mg kg −1 1,2‐DAB to groups of 12 rats, 4 days a week for 11 and 6 weeks, caused a dose‐ and time‐dependent decrease in mean sensory and motor conduction velocities. Recovery in a 5‐week post‐exposure period was gradual but consistent. The effect of 1,2‐DAB on the amplitude of the sensory action potential was ambiguous. The findings support the hypothesis that the formation of 1,2‐diacetylbenzene derivatives contributes to the neurotoxicity of 1,2‐DEB.