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Antidotal effects of dimercaptosuccinic acid
Author(s) -
Ding GuangSheng,
Liang YouYi
Publication year - 1991
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550110103
Subject(s) - antidote , dimercaptosuccinic acid , chemistry , nuclear chemistry , metal poisoning , phosphate , metal , toxicity , environmental chemistry , medicine , heavy metals , biochemistry , organic chemistry , urinary system
Dimercaptosuccinic acid (DMS), HOOC‐CH(SH)‐CH(SH)‐COOH, was first developed in China as an effective antidote for poisoning from many heavy metals, such as Pb, Hg, As, Cd, Sb, TI, Au, Zn, Ni, Pt, Ag, Co and Sn. DMS increases the excretion of Ce, Pm, Sr and Po from the body. Hundreds of patients suffering from hepatolenticular degeneration (Wilson's disease) have been treated successfully with DMS. Recently, DMS was found to be effective also in treating certain non‐metallic intoxications, like some of the new non‐phosphate pesticides and mushroom poisonings.