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Plasma clearance of 51 Cr‐EDTA as an estimator of glomerular filtration rate in conscious rats
Author(s) -
Seefeldt Torben,
Houghton Donald C.
Publication year - 1990
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550100610
Subject(s) - renal function , urology , clearance rate , plasma clearance , metabolic clearance rate , filtration fraction , medicine , chemistry , endocrinology , pharmacokinetics , renal blood flow
Abstract A method is described whereby the plasma clearance of 51 Cr‐EDTA is used to estimate the glomerular filtration rate (GFR) in conscious rats. EDTA clearance rates were calculated based on one and two exponential disappearance curves and compared in groups of animals studied under conditions of normal, high and low GFR. Like previously described related methodologies, this technique obviates the need for urine collections and marker infusions for GFR estimates. An important added advantage is that it provides the opportunity to study animals free of the effects of anesthetic, supine position and surgical stress.