Triiodothyronine (T 3 ) increases cisplatin nephrotoxicity in young and adult rats | Zendy

Appenroth Dorothea | Zendy; Gambaryan Stephan | Zendy; Bakhteeva Vera | Zendy; Winnefeld Klaus | Zendy; Schröter Heinz | Zendy; Gerhardt Steffen | Zendy; Bräunlich Helmut | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Triiodothyronine (T 3 ) increases cisplatin nephrotoxicity in young and adult rats

Author(s) -

Appenroth Dorothea,

Gambaryan Stephan,

Bakhteeva Vera,

Winnefeld Klaus,

Schröter Heinz,

Gerhardt Steffen,

Bräunlich Helmut

Publication year - 1990

Publication title -

journal of applied toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 87

eISSN - 1099-1263

pISSN - 0260-437X

DOI - 10.1002/jat.2550100603

Subject(s) - nephrotoxicity , triiodothyronine , endocrinology , medicine , chemistry , toxicity , proteinuria , cisplatin , urea , blood urea nitrogen , kidney , thyroid , biochemistry , chemotherapy

The influence of pretreatment with triiodothyronine (T 3 ) on cisplatin (CP)‐induced nephrotoxicity was investigated in 10‐ and 55‐day‐old rats. Triiodothyronine pretreatment enhanced CP proteinuria in young and adult rats, and increased blood urea nitrogen concentration in 55‐day‐old rats. As T 3 decreased Pt concentrations in renal tisssue, the enhanced nephrotoxicity of CP by T 3 must have another mechanism. Enhanced CP nephrotoxicity is discussed in connection with an increase of glutathione concentration obtained in renal tissue as a consequence of T 3 pretreatment.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research