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Triiodothyronine (T 3 ) increases cisplatin nephrotoxicity in young and adult rats
Author(s) -
Appenroth Dorothea,
Gambaryan Stephan,
Bakhteeva Vera,
Winnefeld Klaus,
Schröter Heinz,
Gerhardt Steffen,
Bräunlich Helmut
Publication year - 1990
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550100603
Subject(s) - nephrotoxicity , triiodothyronine , endocrinology , medicine , chemistry , toxicity , proteinuria , cisplatin , urea , blood urea nitrogen , kidney , thyroid , biochemistry , chemotherapy
The influence of pretreatment with triiodothyronine (T 3 ) on cisplatin (CP)‐induced nephrotoxicity was investigated in 10‐ and 55‐day‐old rats. Triiodothyronine pretreatment enhanced CP proteinuria in young and adult rats, and increased blood urea nitrogen concentration in 55‐day‐old rats. As T 3 decreased Pt concentrations in renal tisssue, the enhanced nephrotoxicity of CP by T 3 must have another mechanism. Enhanced CP nephrotoxicity is discussed in connection with an increase of glutathione concentration obtained in renal tissue as a consequence of T 3 pretreatment.