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Influence of chronic lead exposure on hormone levels in developing rats
Author(s) -
Vyskočil Adolf,
Fiala Zdeněk,
Ettlerová Eva,
Tenjnorová Iva
Publication year - 1990
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550100412
Subject(s) - medicine , endocrinology , lead acetate , corticosterone , triiodothyronine , hormone , toxicity
The effect of five months' exposure to 0.5% lead acetate in drinking water on hormone levels of developing rats was studied. The hypothalamic and striatic concentrations of noradrenaline (NA) were decreased in both sexes. In female but not in male rats, blood and adrenal catecholamines and serum corticosterone concentrations were aiso increased. No changes were observed in serum thyroxine and 3,5,3′‐triiodothyronine levels. Our results indicate that female developing rats are more susceptible to lead than male rats. In female rats, both the hypothalamo‐pituitary‐adrenal and sympatho‐adrenal systems seem to be affected by this lead exposure; in male rats, only the latter system is affected.