A genotoxicological study of the new local anesthetic carbamate derivatives Carbisocaine, heptacaine and pentacaine | Zendy

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A genotoxicological study of the new local anesthetic carbamate derivatives Carbisocaine, heptacaine and pentacaine

Author(s) -

Siekel Peter

Publication year - 1990

Publication title -

journal of applied toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 87

eISSN - 1099-1263

pISSN - 0260-437X

DOI - 10.1002/jat.2550100403

Subject(s) - carbamate , salmonella , escherichia coli , chemistry , anesthetic , drosophila melanogaster , ethyl carbamate , euglena gracilis , biochemistry , biology , bacteria , food science , anesthesia , genetics , medicine , gene , chloroplast , wine

The potential mutagenic activity of three carbamate derivatives with local anesthetic activity was investigated. Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis , whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimurium, Escherichia coli and Drosophila melanogaster .

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