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The effects of thiamin on the tissue distribution of lead
Author(s) -
Kim Jin Suk,
Blakley Barry R.,
Rousseaux Colin G.
Publication year - 1990
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550100206
Subject(s) - lead acetate , chemistry , body weight , calcium , thiamine , zoology , kidney , endocrinology , lead (geology) , medicine , lead poisoning , toxicity , biochemistry , biology , paleontology , organic chemistry , psychiatry
The effects of thiamin on the tissue distribution of lead were evaluated in Sprague–Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg −1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg −1 body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood ( P > 0.0001), liver ( P < 0.0001) and kidney ( P < 0.0001) concentrations of lead. Thiamin (50 mg kg −1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg −1 body weight). The combined treatment was more effective than the respective individual treatments.