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Acetylation of 5‐aminosalicylate by hamster colon arylamine N ‐acetyltransferase
Author(s) -
Tucker Mark A.,
Smith Timothy J.
Publication year - 1990
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550100114
Subject(s) - chemistry , metabolite , scavenger , hamster , acetylation , biochemistry , microbiology and biotechnology , biology , radical , gene
Abstract Recent evidence suggests that 5‐aminosalicylate acts as an anti‐inflammatory agent by virtue of its ability to act as a free‐radical scavenger. The major metabolite, N ‐acetyl‐5‐aminosalicylate is not an effective free‐radical scavenger. We have demonstrated that an arylamine N ‐acetyltransferase from hamster colon can directly acetylate 5‐aminosalicylate, suggesting that the colon may have the ability to modulate the activity of this agent through metabolic inactivation.