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Relative metabolism of quinones to semiquinone radicals in xanthine oxidase system
Author(s) -
Lewis David C.,
Shibamoto Takayuki
Publication year - 1989
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550090502
Subject(s) - xanthine oxidase , quinone , chemistry , semiquinone , anthraquinones , hypoxanthine , juglone , xanthine , cytochrome , biochemistry , adrenochrome , metabolism , enzyme , biology , botany , epinephrine , endocrinology
Rates of enzymatic single‐electron reduction of some myotoxc quinones to semiquinone metabolites in an in vitro xanthine oxidase/hypoxanthine/catalase system varied widely. Naphthoquinones, especially juglone, were found to undergo rapid single‐electron reduction. Benzoquinones and benzoquinoneimines, as well as phenanthrene‐9,10‐quinone, benzo[ a ]pyrene‐3,6‐quinone, and diethylstilbestrolquinone, were also actively reduced. The anthraquinones danthron, doxorubicin and emodin were poorly metabolized in this system. N ‐Acetylcysteine inhibited quinone‐stimulated cytochrome C reduction at high concentrations. The results of this study are discussed with respect to cytotoxicity and mutagenicity of selected quinones.