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Effects of aflatoxin on the immune system of the chick
Author(s) -
Virdi J. S.,
Tiwari R. P.,
Saxena M.,
Khanna V.,
Singh G.,
Saini S. S.,
Vadehra D. V.
Publication year - 1989
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550090412
Subject(s) - aflatoxin , immune system , biology , titer , antibody , body weight , toxin , antibody titer , antigen , weight gain , zoology , medicine , endocrinology , immunology , microbiology and biotechnology , food science
A decreased antibody response to injected sheep red blood cells and weight losses to the extent of 25–38% were observed in the bursa Fabricii and thymus in chicks fed an aflatoxin diet (10% w/w) for 3 weeks. The immune organs did not show any significant histopathological changes. The antibody titre decreased from day 6 of treatment onward until the 15th day, when the antibody titre had disappeared completely in the test chicks. The body weight gain was also less in test chicks (9.7–37.3%) given test feed or test feed along with Salmonella pullorum in water (10 8 cfu ml −1 ) in comparison to chicks given toxin‐free diet and water after 3 weeks of feeding trials. The disappearing component in the test chicks' liver homogenate was found to be antigenic by immunoelectrophoretic studies.