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Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication
Author(s) -
Uysal Müjdat,
Özdemirler Gül,
Kutalp Güldal,
Öz Hikmet
Publication year - 1989
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550090304
Subject(s) - lipid peroxidation , acetaldehyde , microsome , ethanol , chemistry , microsoma , alcoholic intoxication , liver toxicity , ethanol metabolism , toxicity , pharmacology , biochemistry , medicine , poison control , antioxidant , in vitro , medical emergency , injury prevention , organic chemistry
The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.