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Cadmium toxicity and bioantioxidants: Status of vitamin E and ascorbic acid of selected organs in rat
Author(s) -
Shukla Girja S.,
Chandra S. V.
Publication year - 1989
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550090209
Subject(s) - ascorbic acid , cadmium , endocrinology , medicine , toxicity , vitamin , chemistry , striatum , kidney , cerebellum , hypothalamus , biology , dopamine , food science , organic chemistry
Effects of i.p. administered cadmium acetate (Cd, 0.4 mg/kg) was studied on the levels of vitamin E and ascorbic acid in different brain regions, liver, kidney, testis, RBC and plasma at 15, 30 and 60 days intervals in male albino rats (45 ± 5 g). Exposure to Cd for 15 days decreased the levels of vitamin E significantly in the liver and testis only, while 30 days of treatment resulted in a signifcant decline in cerebellum, cerebral cortex, corpus striatum, mid‐brain + hypothalamus, and plasma. Cadmium administration for 60 days caused a decrease in vitamin E in all tissues. Furthermore, a duration‐dependent decrease in hepatic ascorbic acid levels was noticed. The implications of these results are discussed.