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Rabbit lung after inhalation of lithium chloride
Author(s) -
Johansson Anne,
Camner Per,
Curstedt Tore,
Jarstrand Connie,
Robertson Bengt,
Urban Teresa
Publication year - 1988
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550080507
Subject(s) - lung , inhalation , chemistry , lithium chloride , chloride , lithium (medication) , electron microscope , aerodynamic diameter , toxicity , inhalation exposure , pathology , nuclear chemistry , radiochemistry , endocrinology , medicine , inorganic chemistry , anatomy , aerosol , organic chemistry , physics , optics
Rabbits were exposed to aerosols of lithium chloride in metal concentrations of 0.6 and 1.9 mg/m 3 (mass median aerodynamic diameter of 1 μm) for 4–8 weeks, 5 days/week, 6 h/day. The lungs were studied by light and electron microscopy, with particular reference to inflammatory changes, structure of alveolar macrophages and alveolar epithelial cells. Macrophages recovered by lung lavage were studied by light and electron microscopy and their oxidative metabolic activity was measured. The content of phospholipids was analysed in lung tissue. Exposure to lithium produced no significant effects. It thus seems that Li + is less toxic to the lung than the other metals investigated with the same test system, e.g. Ni 2+ , Cd 2+ , Co 2+ , Cr 3+ and Cr 6+ .