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Studies on the effect of ethanol and/or toluene on rat erythrocytes
Author(s) -
Rosin Janusz,
Bartosz Grzegorz,
WrońskaNofer Teresa
Publication year - 1988
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550080506
Subject(s) - macrocytosis , reticulocyte , ethanol , chemistry , toluene , erythrocyte membrane , red blood cell , lipid bilayer , medicine , biochemistry , endocrinology , membrane , organic chemistry , vitamin b12 , messenger rna , gene
Rats were subjected to a chronic ethanol exposure in their drinking water for 8 months and then a short subacute toluene exposure to 12 000 mg/m 3 for 5 h/day for nine days. Combined exposure increased the reticulocyte count and the concentration of haemoglobin, and changed the biochemical/biophysical properties of red blood cells. Macrocytosis and a decrease in erythrocyte membrane lipid fluidity in the middle zone of the lipid bilayer were the most useful indices of exposure.