A subchronic inhalation study with unleaded petrol in rats | Zendy

Vyskočil Adolf | Zendy; Tušl Miloslav | Zendy; Obršál Jindřich | Zendy; Zaydlar Karel | Zendy

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A subchronic inhalation study with unleaded petrol in rats

Author(s) -

Vyskočil Adolf,

Tušl Miloslav,

Obršál Jindřich,

Zaydlar Karel

Publication year - 1988

Publication title -

journal of applied toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 87

eISSN - 1099-1263

pISSN - 0260-437X

DOI - 10.1002/jat.2550080403

Subject(s) - endocrinology , medicine , corticosterone , inhalation , catecholamine , hypothalamus , spleen , thyroid , kidney , chemistry , adrenal gland , hormone , anesthesia

The effect of intermittent 2 months' exposure to 2 g/m 3 unleaded petrol on the hypothalamo‐pituitary‐thyroid‐adrenal system was evaluated by measuring hypothalamic noradrenaline (NA), serum corticosterone (CS), thyroxine (T 4 ) and adrenal catecholamine (CA) levels in male rats. Serum CS and adrenal CA were increased and hypothalamic NA was decreased by exposure. No changes were observed in serum T 4 . Exposure induced an increase in spleen, kidney, liver and lung weights; weights of adrenals and hypothalamus were not changed. All the petrol‐induced effects depended on the length of exposure. Rats exposed to petrol gained less weight than controls. The results suggest a non‐specific stress response in the rat.

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