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A subchronic inhalation study with unleaded petrol in rats
Author(s) -
Vyskočil Adolf,
Tušl Miloslav,
Obršál Jindřich,
Zaydlar Karel
Publication year - 1988
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550080403
Subject(s) - endocrinology , medicine , corticosterone , inhalation , catecholamine , hypothalamus , spleen , thyroid , kidney , chemistry , adrenal gland , hormone , anesthesia
The effect of intermittent 2 months' exposure to 2 g/m 3 unleaded petrol on the hypothalamo‐pituitary‐thyroid‐adrenal system was evaluated by measuring hypothalamic noradrenaline (NA), serum corticosterone (CS), thyroxine (T 4 ) and adrenal catecholamine (CA) levels in male rats. Serum CS and adrenal CA were increased and hypothalamic NA was decreased by exposure. No changes were observed in serum T 4 . Exposure induced an increase in spleen, kidney, liver and lung weights; weights of adrenals and hypothalamus were not changed. All the petrol‐induced effects depended on the length of exposure. Rats exposed to petrol gained less weight than controls. The results suggest a non‐specific stress response in the rat.