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The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat
Author(s) -
Barrett R. J.,
Harleman J. H.,
Joseph E. C.
Publication year - 1988
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550080402
Subject(s) - necrosis , isozyme , endocrinology , isoprenaline , medicine , enzyme , chemistry , biochemistry , stimulation
The total LDH, HBDH and LDH isoenzyme activities were assessed in a number of rat tissues. HBDH did not correlate with LD 1 and LD 2 isoenzyme activity in tissues with high HBDH activity. HBDH therefore cannot be used as a marker for cardiac necrosis in the rat. In rats treated with isoprenaline and SK&F 94120 at doses producing myocardial necrosis, only the LD 1 isoenzymes showed any significant change but only within the first 24 h of treatment. No statistically significant differences were seen in the plasma AST, CK, CK‐MB and total LDH activities.