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An illustration of dangers of ignoring survival differences in carcinogenic data
Author(s) -
Bailer A. John,
Portier Christopher J.
Publication year - 1988
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550080306
Subject(s) - carcinogenesis , carcinogen , survival analysis , oncology , toxicology , medicine , biology , statistics , cancer , mathematics , genetics
This paper illustrates the effects of survival differences on the routine analysis of 2‐year animal carcinogenesis experiments using quantal response. Not adjusting for decreased survival in the higher dosed groups results in a decrease in the actual significance level for the quantal response trend test, and a corresponding decrease in sensitivity for detecting a true treatment effect. Similar results hold for estimation of carcinogenic risk. Tables of the range of survival differences found in recent National Toxicology Program carcinogenesis studies are presented.