Hepatotoxic effects elicited by  n ‐hexane or  n ‐ heptane | Zendy

Goel S. K. | Zendy; Rao G. S. | Zendy; Pandya K. P. | Zendy

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Hepatotoxic effects elicited by n ‐hexane or n ‐ heptane

Author(s) -

Goel S. K.,

Rao G. S.,

Pandya K. P.

Publication year - 1988

Publication title -

journal of applied toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 87

eISSN - 1099-1263

pISSN - 0260-437X

DOI - 10.1002/jat.2550080203

Subject(s) - heptane , hexane , chemistry , endocrinology , lipid peroxidation , medicine , microsome , solvent , alkaline phosphatase , enzyme , biochemistry , chromatography , biology , organic chemistry

Hepatotoxic effects of n ‐hexane and n ‐heptane administered i.p. (1 ml/kg body wt) were studied in albino rats after 1, 2, 7 and 45 days of treatment. Hepatic protein content decreased with n ‐heptane and total sulphydryl content showed a significant decrease in the rats exposed to either solvent. A significant increase in lipid peroxidation was observed after 24 h and 48 h exposure to n ‐hexane or n ‐heptane. A marked decrease in drug metabolizing activity and an increase in pentabarbitone sleeping time was also observed. Hepatic glucose‐6‐phosphatase, a microsomal marker enzyme, showed a significant decrease.

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