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Hepatotoxic effects elicited by n ‐hexane or n ‐ heptane
Author(s) -
Goel S. K.,
Rao G. S.,
Pandya K. P.
Publication year - 1988
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550080203
Subject(s) - heptane , hexane , chemistry , endocrinology , lipid peroxidation , medicine , microsome , solvent , alkaline phosphatase , enzyme , biochemistry , chromatography , biology , organic chemistry
Hepatotoxic effects of n ‐hexane and n ‐heptane administered i.p. (1 ml/kg body wt) were studied in albino rats after 1, 2, 7 and 45 days of treatment. Hepatic protein content decreased with n ‐heptane and total sulphydryl content showed a significant decrease in the rats exposed to either solvent. A significant increase in lipid peroxidation was observed after 24 h and 48 h exposure to n ‐hexane or n ‐heptane. A marked decrease in drug metabolizing activity and an increase in pentabarbitone sleeping time was also observed. Hepatic glucose‐6‐phosphatase, a microsomal marker enzyme, showed a significant decrease.