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Acute and subchronic toxicity of tetramethylcyclohexanes
Author(s) -
Johannsen Frederick R.,
Levinskas George J.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070404
Subject(s) - nephrosis , toxicity , kidney , urine , acute toxicity , food consumption , oral administration , medicine , median lethal dose , chemistry , physiology , toxicology , endocrinology , biology , agricultural economics , economics
The acute oral toxicity in rats was estimated for seven isomers or isomeric ratios of tetramethylcyclohexane (TMCH). Lack of sufficient mortality at the highest dosage test (15.8 g/kg) precluded evaluation of an LD50 for mixed cis, trans ‐isomers of 1,2,3,4‐TMCH, 1,2,3,5,‐TMCH, 1,2,4,5‐TMCH and 1,1,2,3‐TMCH, for the separate cis ‐ or trans ‐forms of 1,1,3,5‐TMCH or a 1:1 mixture of c , t −1,1,3,5‐TMCH and c , t −1,2,3,4‐TMCH. Mixed ( c , t ‐combined) isomeric TMCH was administered oraiiy to rats (30/group) and dogs (8/group) for 90 days at dietary levels of 0, 3000, 10 000 and 30 000 ppm TMCH and 0, 100, 300 and 1000 ppm TMCH, respectively. Administration of up to 30 000 TMCH to rats produced no discernible effects on survival, behavior, growth, food consumption, clinical blood picture or urine analysis. Absolute kidney weights of male but not female rats were elevated at all test levels. TMCH‐related microscopic lesions were confined to the kidney of male rats in all treated groups. These histopathologic changes were characteristic of tubular nephrosis. No treatment‐related effects were observed in groups of dogs fed up to 1000 ppm TMCH for 90 days.