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Teratologic studies on alcide Allay® gel in rabbits
Author(s) -
AbdelRahman Mohamed S.,
Skowronski Gloria A.,
Gerges Samy E.,
von Hagen Stanley,
Turkall Rita M.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070303
Subject(s) - medicine , fetus , gestation , placebo , erythema , teratology , pregnancy , physiology , surgery , biology , pathology , genetics , alternative medicine
Alcide Allay® gel, a highly effective germicidal compound, was evaluated for teratogenic potential in rabbits. Pregnant rabbits were administered 2 g/kg Allay® get (containing either of two concentrations of sodium chlorite as active ingredient) or placebo topically on days 6–18 of gestation. Moderate to severe erythema was recorded in the high‐dose gel group on day 11 (Draize score = 3.5). By day 18, the skin of all rabbits in the high dose treatment group appeared normal. Decreased maternal body weight gain was observed in the low dose and placebo gel groups. Fetal weights and lengths were significantly reduced in all gel groups. There was some incidence of skeletal anomalies in all gel treated groups, however, these incidences were not statistically different from the control group. The commonly occurring skeletal defects were incomplete ossification of skull bones, small or missing sternebrae, and extra ribs. The incidence of visceral abnormalities in all gel groups was not statistically different from control animals. Visceral anomalies included heart displacement, fusion or serration of the liver, and kidney displacement. Alcide Allay® gel at 2 g/kg was non‐teratogenic to rabbit fetuses.