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Sensory irritation of methylisocyanate vapor
Author(s) -
James John T.,
Buettner Leonard C.,
Hsu Sam S.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070213
Subject(s) - irritation , respiratory system , depression (economics) , toxicology , environmental chemistry , medicine , chemistry , biology , immunology , economics , macroeconomics
The respiratory‐depression (RD) profile in mice exposed to methylisocyanate (MIC) vapor is reported. The RD 50 value calculated from this profile was 2.9 (2.7–3.2) ppm. Concentrations of MIC that have been reported to be unbearable in humans were of approximately the same magnitude as RD 50 concentrations in mice for brief exposures.