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Pyrethroid inhibition of basal and calmodulin stimulated Ca 2+ ATPase and adenylate cyclase in rat brain
Author(s) -
Kabeer Sahib I. Ahammad,
Rao K. S. Prasada,
Desaiah D.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070202
Subject(s) - adenylate kinase , cyclase , calmodulin , atpase , basal (medicine) , chemistry , endocrinology , medicine , biochemistry , microbiology and biotechnology , enzyme , biology , insulin
Effects of two classes of pyrethroids, permethrin and resmethrin (type I), cypermethrin and deltamethrin (type II), on basal (calmodulin‐deficient) and calmodulin stimulated activities of Ca 2+ ATPase and adenylate cyclase from rat brain were studied in vitro . None of the pyrethroids inhibited synaptosomal basal Ca 2+ ATPase, but permethrin and deltamethrin inhibited basal adenylate cyclase in the nuclear fraction of a brain homogenate. Both groups of pyrethroids decreased the calmodulin activated Ca 2+ ATPase and adenylate cyclase from brain synaptosomes and nuclear fraction. The results indicate that calmodulin‐stimulated Ca 2+ ATPase is more sensitive to type II pyrethroids and pyrethroids are more effective on calmodulin stimulated enzymes than basal enzyme activities. Since calmodulin, adenylate cyclase and Ca 2+ ATPase are known to participate in various brain processes, it is possible that pyrethroids alter neural transmission, however, additional in vivo work would be needed to confirm this possibility.