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The potentiation of the non‐behavioural effects of amphetamine by carbon disulphide
Author(s) -
Caroldi Stefano,
Magos Laszlo,
Jarvis Jack,
Forshaw Philip,
Snowden Roger T.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070111
Subject(s) - long term potentiation , amphetamine , pharmacology , dextroamphetamine , chemistry , psychology , neuroscience , medicine , receptor , dopamine
In agreement with the inhibition of dopamine‐β‐hydroxylase by exposure to CS 2 , the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus. The extension of exposure time also increased the toxicity of amphetamine. In conscious animals the stereotypic activity produced by 6.0 mg/kg and even that of 3.0 mg/kg amphetamine sulphate was suppressed by severe hyperthermia resulting in exhaustion, prostration and eventually death. A 16h exposure to CS 2 did not increase the lethal or hyperthermic effects of amphetamine in rats anaesthetized with 60 mg/kg sodium pentobarbitone. In fact the CS 2 exposed rats became more hypothermic than non‐exposed rats.