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Acute toxicity of the major alkaloids of cultivated Lupinus angustifolius seed to rats
Author(s) -
Petterson D. S.,
Ellis Z. L.,
Harris D. J.,
Spadek Z. E.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070109
Subject(s) - lupinus angustifolius , clearance , alkaloid , toxicity , intraperitoneal injection , acute toxicity , lethal dose , median lethal dose , biology , botany , toxicology , pharmacology , medicine , urology
Abstract The seed of modern cultivars of Lupinus angustifolius normally contain less than 0.03% alkaloids. The acute oral LD 50 to rats of a prorata mixture of the alkaloids of L. angustifolius seed was found to be 2279 mg/kg. For lupanine the LD 50 by oral administration was 1464 mg/kg and by intraperitoneal injection 177 mg/kg. For 13‐hydroxylupanine the LD 50 by intraperitoneal injection was 199 mg/kg. Since these two alkaloids comprise about 85% of the total and are known to be rapidly cleared from the body it is suggested that the alkaloids in this species do not pose a health problem for man.