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Subacute (4‐week) inhalation toxicity study of formaldehyde in male rats: 8‐hour intermittent versus 8‐hour continuous exposures
Author(s) -
Wilmer J. W. G. M.,
Woutersen R. A.,
Appelman L. M.,
Leeman W. R.,
Feron V. J.
Publication year - 1987
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550070104
Subject(s) - formaldehyde , inhalation , histopathology , inhalation exposure , toxicity , physiology , medicine , chemistry , toxicology , anesthesia , pathology , biology , biochemistry
Male Wistar rats were exposed for 4 weeks, 5 days a week, to 0 (controls), 5 or 10 ppm formaldehyde continuously (8 hours a day), or to 10 or 20 ppm formaldehyde interruptedly (eight 30 min exposure periods separated by 30 min non‐exposure periods). Histopathology and cell proliferation studies indicated that under the conditions of exposure used, concentration rather than the total dose of formaldehyde determined the severity of the cytotoxic effects on the nasal epithelium.