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Platelet population profiles: Significance of species variation and drug‐induced changes
Author(s) -
Eason C. T.,
Pattison A.,
Howells D. D.,
Mitcheson I.,
Bonner F. W.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060610
Subject(s) - platelet , marmoset , mean platelet volume , population , biology , immunology , medicine , ecology , environmental health
Platelet counts are routinely assessed from whole blood samples and recent technical advances enable the total platelet counts to be complemented by additional information which fully profiles the platelet population. In this report the platelet count, mode and mean platelet volumes and platelet profile histograms are presented for eight mammalian species. Species and strain variation in platelet profiles and the degree of volume heterogeneity are presented, and a platelet profile is presented for the marmoset which is previously unreported. The significance of these parameters and their potential importance to the toxicologist are disussed in the light of an observation of a drug‐induced altertaino in a platelet population profile.