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Influnce of manganese on the gastrointestinal absorption of cadmium in rats
Author(s) -
Sarhan Mohammad J.,
Roels Harry,
Lauwerys Robert,
Reyners Hubert,
De Reyners Elva Gianfelici
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060503
Subject(s) - cadmium , chemistry , urine , manganese , kidney , absorption (acoustics) , medicine , gastrointestinal tract , cadmium poisoning , endocrinology , nuclear chemistry , biochemistry , materials science , organic chemistry , composite material
Four groups of male rats were given the following oral treatment: control group (n = 20) deionized drinking water, Mn group (n = 20) deionized drinking water containing 56 ppm Mn 2+ (1 mmol/l), Cd group (n = 10) deionized drinking water containing 112 ppm Cd 2+ (1 mmol/l) and Cd+Mn group (n = 10) deinonized drinking water containing 112 ppm Cd 2+ and 56 ppm Mn 2+ . Half of each group was sacrificed after 4 weeks and the other half after 8 weeks of treatment. At each time interval, the mean levels of Mn in blood, in urine and in the various tissus did not differ between the control and Mn groups. Furthermore, comparable Mn levels were found after 4 and 8 weeks of treatment. Microscopical examination of the brain failed to reveal any overt morphological alteration in the Mn group. With respect to the control group, the Cd and Cd + Mn groups exhibited increased levels of Cd in blood, urine, liver, whole kidney, kidney cortex and in brain (cortex, cerebellum, basal ganglia), but the Cd + Mn groups showed invariably lower levels than the Cd group after 4 weeks as well as after 8 weeks. These results suggest that the rate of gastrointestinal absorption of Cd is decreased by supplementation of the drinking water with a ‘non‐toxic’ dose of Mn 2+ .