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Stimulation of lipid peroxidation and impairment of glutathione‐dependent defence system in the liver of rats repeatedly treated with carbon tetrachloride
Author(s) -
Yalçin A. Süha,
KoçakToker Necla,
Uysal Müjdat,
Aykaç Gülçin,
Sivas Ahmet,
Öz Hikmet
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060413
Subject(s) - carbon tetrachloride , lipid peroxidation , glutathione , chemistry , glutathione peroxidase , gpx4 , stimulation , endocrinology , medicine , antioxidant , biochemistry , pharmacology , enzyme , biology , organic chemistry
To study the effect of carbon tetrachloride treatment on hepatic lipid peroxidation and glutathione‐dependent defence system, rats were injected with carbon tetrachloride (0.2 ml/kg body weight, i.p.) twice weekly for a period of 4 weeks. Carbon tetrachloride treatment caused a significant increase in hepatic lipid peroxide levels and significant decreases in hepatic glutathione levels and glutathione peroxidase and glutathione transferase activities. These results show that chronic carbon tetrachloride administration to rats leads to the stimulation of hepatic lipid peroxidation, which seems to be the consequence of impaired cellular defence by glutathione and glutathione‐related enzymes.