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The distribution of arsenic and cobalt in patients with laryngeal carcinoma
Author(s) -
Collecchi Paola,
Esposito Mauro,
Brera Silvio,
Mora Enzo,
Mazzucotelli Ambrogio,
Oddone Massimo
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060410
Subject(s) - arsenic , cobalt , carcinoma , chemistry , medicine , pathology , inorganic chemistry , organic chemistry
The objective of this study was to evaluate tissue and plasma concentrations of arsenic and cobalt in an attempt to discove the role of these elements in the malignant process. Using neutron activation analysis, arsenic and cobalt levels were determined in plasma and in non‐malignant and malignant human tissue in 15 patients with laryngeal carcinoma. Arsenic and cobalt levels were about 60% higher in tumor than in adjacent non‐malignant tissue ( P <0.001): arsenic 72.4±18.0 ng/g versus 43.1±9.4 in non‐malignant tissues, and cobalt 68.7±7.3 ng/g versus 39.6±7.0 in non‐malignant tissues. Mean plasma arsenic and cobalt levels were also significantly higher in patients with laryngeal carcinoma than in healthy control subjects.