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Urinary α 1 ‐microglobulin as an indicator protein of renal tubular dysfunction caused by environmental cadmium exposure
Author(s) -
Tohyama Chiharu,
Kobayashi Etsuko,
Saiko Hiroshi,
Sugihara Naoko,
Nakano Atsuhiro,
Mitane Yuko
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060307
Subject(s) - cadmium , beta 2 microglobulin , urinary system , cadmium exposure , cadmium poisoning , medicine , kidney , toxicity , urology , endocrinology , chemistry , toxicology , biology , organic chemistry
An epidemiologic investigation was carried out to clarify the significance of the urinary excretion of α 1 ‐microglobulin (α 1 ‐MG) in people aged 50 years and over living in a Cd‐polluted area in Japan. Approximately 80% of the population participated in the health examination. The urinary and serum levels and the relative clearance of α 1 ‐MG to creatinine clearance were compared with various parameters (age, urinary β 2 ‐microglobulin (β 2 ‐MG), total protein, Cd, Cu and Zn, serum β 2 ‐MG, creatinine and blood urea nitrogen and relative clearances of α 1 ‐MG, β 2 ‐MG, inorganic phosphate and uric acid). It was found that the urinary excretion of α 1 ‐MG is closely associated with the urinary Cd and Cu and with the indices of renal dysfunction listed above. These results suggest that the urinary α 1 ‐MG level masrkedly reflects a degree of proximal tubular dysfunction and that it may be useful as one of the screening measures for proximal tubular dysfuction caused by environmental Cd exposure.