Toxic response of hamster embryo cells on exposure to mixtures of Ni 2+  and benzo( a )pyrene | Zendy

Uziel M. | Zendy; Owen B. | Zendy; Butler A. | Zendy

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Toxic response of hamster embryo cells on exposure to mixtures of Ni 2+ and benzo( a )pyrene

Author(s) -

Uziel M.,

Owen B.,

Butler A.

Publication year - 1986

Publication title -

journal of applied toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 87

eISSN - 1099-1263

pISSN - 0260-437X

DOI - 10.1002/jat.2550060306

Subject(s) - pyrene , benzo(a)pyrene , excretion , hamster , chemistry , embryo , benzopyrene , toxicity , ecotoxicology , toxicology , biochemistry , environmental chemistry , microbiology and biotechnology , biology , organic chemistry , genetics

Exposure of hamster embryo cells (HEC) to mixtures of benzo( a ) pyrene and soluble Ni 2+ neutral salts elicits additive responses in the enhanced nucleoside excretion assay. Ni 2+ shows no significant excretion response until concentrations near 10 μM are reached. Addition of 0.4 micromolar benzo( a )pyrene and 30 μM, or 325 μM Ni 2+ to HEC cultures results in total excretion equal to the sum of excretions induced by the individual chemicals. These observations suggest that excretion of pyrimidines may be a useful measure of biological dosimetry.

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