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Estimation of acute oral toxicity in rates by determination of the approximate lethal dose rather than the LD 50
Author(s) -
Kennedy Gerald L.,
Ferenz Rayanne L.,
Burgess Bruce A.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060302
Subject(s) - median lethal dose , toxicity , lethal dose , acute toxicity , toxicology , oral dose , oral administration , medicine , chemistry , pharmacology , biology
The approximiate lethal dose (ALD) to rats following oral administration of nine chemicals was determined. The ALD (lowest dose at which death was produced) for each chemical was used to define the general order of toxicity as being either extremely, highly, moderately, slightly, or practically non‐toxic. For each of the nine chemicals tested, the category indicated by the ALD was identical with the category determined in the more extensive LD 50 studies. In this study, an average of 6.8 rats was needed to determine the ALD while an average of 56.3 rats was needed to determine the LD 50 .