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Neurotoxicity assessment of O‐ethyl‐O'‐(2‐diisopropylaminoethyl) methylphosphonite (QL) in hens
Author(s) -
Olajo E. J.,
Bergmann J.,
Weimer J. T.,
Wall H.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060213
Subject(s) - neurotoxicity , toxicity , dosing , aché , toxicology , pharmacology , chemistry , medicine , biology , acetylcholinesterase , biochemistry , enzyme
O‐ethyl‐O'‐(2‐diisopropylaminoethyl) methylphosphonite (QL), an intermediate in the formation of ethyl S‐2‐diisopropylaminoethyl methylphosphonothiolate, was evaluated for neurotoxicity in the adult hen. Birds were given a single oral dose of QL ranging from 635 to 6080 mg kg −1 . The QL‐treated hens were observed for up to 24 h after dosing for acute toxicologic effects and over a 24 d post‐dose period for evaluation of delayed neurotoxicity. The oral LD 50 in hens is 1186 mg kg −1 . Neurologic dysfunction, as evidenced by motor incapacitation, was observed at 6 days and thereafter after treatment with QL. Neurotoxic esterase (NTE) activity was not inhibited at 24 h after exposure to compound. Neural damage, multifocal in nature, was noted in the peripheral nervous system of QL‐treated hens at dose levels ≥ 635 mg kg −1 , oral dose. These findings indicate neural damage tendencies following QL exposure.