Premium
The effects of chronic ozone exposure on pulmonary collagen content and collagen synthesis in rats
Author(s) -
Filipoicz C.,
McCauley R.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060204
Subject(s) - lung , proline , ozone , chemistry , endocrinology , medicine , biochemistry , pathology , amino acid , organic chemistry
Male rats were exposed to 0.125, 0.25 or 0.5 ppm of ozone or clean air for up to 1 year. During this exposure period there was little evidence for collagen accumulation in the lungs. However, the rate of incorporation of tritriated proline into both lung collagen and total lung protein was accelerated. These data suggest that exposure to ozone under these conditions results in an increase in the turnover of collagen as well as other lung proteins.