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The relative induction of mixed‐function oxidase specific activity to CH and CC1 bond strengths in polychlorinated derivatives of dibenzo‐ p ‐dioxin (PCDDs)
Author(s) -
Brownlee L. J.,
Evans C. H.,
Hollebone B. R.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060114
Subject(s) - mixed function oxidase , chemistry , polychlorinated dibenzofurans , pyrene , chlorine , chlorine atom , hydroxylation , environmental chemistry , medicinal chemistry , microsome , organic chemistry , enzyme
The structure–activity relationships between the mixed‐function oxidase (MFO) system and six polychlorinated derivatives of dibenzo‐ p ‐dioxin (PCDDs) were studied using Sprague Dawley rats. The study was set up in accordance with previous work in these laboratories involving monocyclic hydrocarbons. Three possible mechanisms at the MFO active site are proposed. C—H bond hydroxylation in low chlorine substituted PCDDs, and probable exposidation in the intermediate chlorinated species including 2378 tetrachlorodibenzodioxin. Benzo[a]pyrene activity induced by some PCDDs appears irrelevant to the desired metabolic result.