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A correlation of induced mixed‐function oxidase specific activity to C—H bond strengths in partially chlorinated monocyclic hydrocarbons
Author(s) -
Brownlee L. J.,
Hollebone B. R.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060113
Subject(s) - mixed function oxidase , cyclohexane , chemistry , chlorobenzene , benzene , hydrogen bond , inductive effect , ring (chemistry) , streptopelia , substrate (aquarium) , function (biology) , aryl , steric effects , stereochemistry , biochemistry , organic chemistry , enzyme , molecule , biology , cytochrome , genetics , ecology , catalysis , alkyl , political science , law , dove
Abstract The nature of structure–function relationships between the mixed‐function oxidase (MFO) system and certain chemically related xenobiotics has been studied. The total hepatic induction index has been modified and used to investigate whether the induction of hepatic MFO is primarily a response to molecular shape (entropic) or to the strength of specific carbon–hydrogen bond strength (enthalpic). Using both Sprague‐Dawley male rats and ring doves ( Streptopelia risoria ) and testing with benzene, 1,2,4‐trichlorobenezene, cyclohexane and γ‐1,2,3,4,5,6,‐hexachlorocyclohexane as both inducers and substrates, a response of the MFO system to substrate C—H bond strength has been found.