Premium
Intestinal absorption of aluminum in rats: Effect of intraluminal pH and aluminum concentration
Author(s) -
van der Voet Gijsbert B.,
de Wolff Frederik A.
Publication year - 1986
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550060108
Subject(s) - jejunum , chemistry , ileum , absorption (acoustics) , perfusion , chloride , medicine , aluminium , endocrinology , chromatography , biochemistry , biology , materials science , organic chemistry , composite material
The intestinal absorption of aluminum (Al) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The jejunum‐ileum was perfused with media containing 4.63, 9.25 and 18.50 mmol l −1 Al chloride at pH 4.0 and 7.0. Both mucosal retention and release of Al into the blood increased at increasing perfusate concentrations. Mucosal retention was not affected by pH but at lower pH more Al was released into the blood. The amount of Al which appeared in the blood was linearly related to the mucosal retention. The Al release into the blood was much less (μmol l −1 ) than the mucosal retention (mmol l −1 ). It is concluded that the intestinal absorption of Al is pH‐ and concentration‐dependent.