Premium
Toxicity of aromatic disulphides. II. Intra‐erythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides
Author(s) -
Munday R.
Publication year - 1985
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550050614
Subject(s) - hydrogen peroxide , chemistry , oxidative phosphorylation , in vitro , peroxide , reactive oxygen species , amino acid , medicinal chemistry , biochemistry , organic chemistry
Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro . It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non‐protein and protein‐bound thiols) in these cells. Such changes were also recorded in erythrocytes exposed to 4,4′ ‐diaminodiphenyl disulphide, 2,2′‐diaminodiphenyl disulphide, 4,4′‐dimethyldiphenyl disulphide, 4,4′‐dinitrodiphenyl disulphide, diphenyl disulphide‐2,2′‐dicarboxylic acid and dibenzyl disulphide. The relative potency of these coumpounds in causing erythrocyte damage is correlated with their ability to generate ‘active oxygen’ species in vitro .