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Biogenic amines and some metals in brain of cadmium‐exposed diabetic rats
Author(s) -
Chandra Satya V.,
Kalia Kiran,
Hussain Tahir
Publication year - 1985
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550050608
Subject(s) - cadmium , alloxan , diabetes mellitus , chemistry , endocrinology , medicine , zinc , toxicity , neurotoxicity , organic chemistry
Abstract Diabetic rats (alloxan diabetes) were exposed to cadmium (2 mg kg −1 i.p.) daily for 21 days to investigate the levels of blood glucose, biogenic amines and iron, copper, zinc and cadmium in the brain. Cadmium exposure to diabetic rats produced a significant exacerbation in the hyperglycemic effect and accumulation of cadmium in the blood compared with that observed after diabetes or cadmium exposure alone. The elevation in the levels of brain dopamine and 5‐hydroxytryptamine were also more pronounced in cadmiumexposed diabetic rats compared with either cadmium exposure or diabetes alone. Cadmium exposure to diabetic rats also produced significant changes in the concentrations of copper in the blood. These results indicated enhanced cadmium toxicity in diabetic rats.