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Hepatotoxicity in albino rats exposed to n ‐octane and n ‐nonane
Author(s) -
Khan Sumsullah,
Pandya K. P.
Publication year - 1985
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550050205
Subject(s) - nonane , endocrinology , chemistry , albumin , medicine , octane , esterase , liver function , aldolase a , intraperitoneal injection , serum albumin , enzyme , biochemistry , biology , organic chemistry
Abstract Effects of n ‐octane and n ‐nonane (1 ml per kg body weight daily) on hepatic and serum enzymes, which reflect abnormal liver function and concentration of lipid and nucleic acid (serum and liver), were studied after 2 and 7 days intraperitoneal administration to albino rats. Decreased activities of serum acetylcholine esterase and carboxyl esterase were observed, together with an increase in FDP aldolase activity. Significant decrease in the concentration of albumin, total protein, and total and esterified cholesterol in serum have been noted after n ‐octane and n ‐nonane administration for 7 days. Also, free cholesterol content of liver was elevated significantly after solvents exposure.