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Chromosomal aberrations and fetotoxic effects of atmospheric arsenic exposure in mice
Author(s) -
Nagymajtényi L.,
Selypes A.,
Berencsi G.
Publication year - 1985
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550050204
Subject(s) - arsenic , fetus , gestation , toxicity , arsenic toxicity , prenatal exposure , andrology , biology , physiology , pregnancy , medicine , zoology , chemistry , genetics , organic chemistry
Fetal chromosomal damage and toxicity were investigated in mice exposed to the atmospheric concentrations of 28.5 mg m −3 , 2.9 mg m −3 and 0.26 mg m −3 of arsenic for 4 h per day on the 9th, 10th, 11th and 12th days of gestation. On the 18th day, the fetuses were removed, and the following parameters were examined: the number of dead fetuses, retardation in growth, osteogenesis and chromosomal aberrations in liver cells. It was found that exposure to As 2 O 3 at 28.5 mg m −3 caused fetotoxic effects and chromosomal damage, while the two lower exposures produced no significant changes with the exception of a slight decrease (9.9 and 3.1%, respectively) in fetal weight.