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Nuclear enlargement – an early change produced in mouse epidermis by carcinogenic chemicals applied topically in the presence of a promoter
Author(s) -
Ingram Andrew John,
Grasso Paul
Publication year - 1985
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550050203
Subject(s) - croton oil , carcinogen , epidermis (zoology) , chemistry , croton , toxicology , biology , biochemistry , immunology , anatomy , organic chemistry , inflammation
A series of 27 compounds, including 11 polycyclic hydrocarbons, 8 proximate carcinogens and 8 other compounds, were tested for their ability to induce epidermal nuclear enlargement in mouse skin. The materials were applied topically in methyl ethyl ketone containing 0.1% croton oil, repetitively for 3 days. Nuclear enlargement present on the fourth day was determined with the aid of a Quantiment image‐analysing computer. The results obtained indicated a close correlation between the topical carcinogenicity of the test compounds and their ability to induce epidermal nuclear enlargement in the presence of croton oil.