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The effects of fasting on the acute oral toxicity of nine chemicals in the rat
Author(s) -
Dashiell O. L.,
Kennedy Gerald L.
Publication year - 1984
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550040608
Subject(s) - toxicity , median lethal dose , acute toxicity , chemistry , corn oil , oral administration , pharmacology , potency , toxicology , medicine , endocrinology , biochemistry , biology , in vitro
Nine chemicals, with a range from extremely to slightly toxic, were used to measure the oral LD 50 in both fasted (24‐h) and non‐fasted rats. Each chemical was tested as a solution or suspension in corn oil, responses within 14 days post‐treatment were evaluated, and LD 50 s were calculated. Hexachlorophene was more toxic in non‐fasted rats. The LD 50 values for tetraethyl lead, methomyl and hexamethylenediamine were essentially the same in both fasted and non‐fasted rats. Adiponitrile, bromobenzene, caffeine, carbon tetrachloride and N ‐butyl‐1,6‐hexamediamine yielded lower LD 50 values in fasted rats. The use of non‐fasted rats in acute oral toxicity determinations allows both the establishment of relative potency and the estimation of dosage levels for further repeated dose oral studies. The LD 50 values obtained were generally (7 of 9) higher in non‐fasted rats, but the magnitude of the differences was not great enough to suggest routine use of both fasted and non‐fasted rats in oral toxicity studies.